Adrenal steroidogenesis includes three main pathways, leading to cortisol, aldosterone and androgen synthesis, with androgens eventually being aromatized (converted to estrogens). Adrenal glandareas and zones with respective hormones synthesizedĬholesterol (low-density lipoprotein or LDL) is the precursor for adrenal steroidogenesis. The medulla serves as the site of catecholamine, metanephrine and normetanephrine synthesis.įigure 9.
The cortex is further divided in 3 zones (zona glomerulosa or site of aldosterone synthesis, zona fasciculata or site of cortisol synthesis and zona reticularis or site of androgen synthesis). The adrenal gland is divided into twodistinct areas, the cortex and the medulla.
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